<?xml version="1.0" encoding="UTF-8" standalone="yes"?><oembed><version><![CDATA[1.0]]></version><provider_name><![CDATA[amphoteros]]></provider_name><provider_url><![CDATA[http://amphoteros.com]]></provider_url><author_name><![CDATA[ayudin2013]]></author_name><author_url><![CDATA[https://amphoteros.com/author/ayudin2013/]]></author_url><title><![CDATA[Proton/deuterium exchange]]></title><type><![CDATA[link]]></type><html><![CDATA[<p>There are no protein reports today&#8230; I am waiting to hear on the news from the synchrotron (tomorrow). For a change, today I am going back to MUCH smaller molecules. I was thinking if I can come up with an interesting question involving some really well known reagents that seem almost too trivial. The venerable borohydride came to mind! Take a look at the equilibrium shown below. This process can be driven to the right, offering a means to make borodeuteride. The finding comes from a rather old paper (I can post it in the future). I did not balance the equation and decided to just leave the bare bones of the central idea. What do you think is the mechanism of this exchange process? <a href="https://amphoteros.files.wordpress.com/2013/07/exchange.jpg"><img class="size-full wp-image aligncenter" id="i-115" alt="Image" src="https://amphoteros.files.wordpress.com/2013/07/exchange.jpg?w=487" srcset="https://amphoteros.files.wordpress.com/2013/07/exchange.jpg?w=487 487w, https://amphoteros.files.wordpress.com/2013/07/exchange.jpg?w=974 974w, https://amphoteros.files.wordpress.com/2013/07/exchange.jpg?w=150 150w, https://amphoteros.files.wordpress.com/2013/07/exchange.jpg?w=300 300w, https://amphoteros.files.wordpress.com/2013/07/exchange.jpg?w=768 768w" sizes="(max-width: 487px) 100vw, 487px" /></a></p>
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