“In theory, it is possible to use the Sudoku method to sequence more than a hundred thousand DNA samples,” says CSHL Professor Gregory Hannon, Ph.D., a genomics expert and leader of the team that invented the “Sudoku” approach. At that level of efficiency, it promises to reduce costs dramatically. A sequencing project that costs upwards of $10 million using conventional methods may be accomplished for $50,000 to $80,000 using DNA Sudoku, he estimates.